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Neuropsychological Characterization of Patients With Bipolar Disorder and a History of Suicide Attempt | Clinical Trials | Clareo Health

WITHDRAWN

Neuropsychological Characterization of Patients With Bipolar Disorder and a History of Suicide Attempt

NCT02116400•Centre Hospitalier Universitaire de Nīmes

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Summary

The main objective of this study is to evaluate decision-making using the Iowa Gambling Task (IGT) among patients with euthymic bipolar disorder according to their personal history of suicide attempt ("suicidal" vs. "not suicidal ").

Detailed Description

The secondary objectives of this study are: A. Evaluate other aspects of cognitive functioning (using the Tower of London, the Probabilistic Reversal-learning task, the Rey Complex Figure, the Reading the Mind in the Eyes test) in euthymic patients with bipolar disorder, depending on the presence or absence of a history of suicide attempt; B. Explore performance on neuropsychological tests depending on the type of therapy administered (lithium salts or valproate monotherapy or in combination with other mood stabilizers); C. Explore a possible relationship between circulating levels of lithium or sodium divalproex results and different neuropsychological tests; D. Establishment of a biobank for this population with leftover blood samples following serum lithium or divalproex testing.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•The patient was correctly informed about the study
•The patient must be insured or beneficiary of a health insurance plan
•The diagnosis of bipolar disorder is confirmed by the doctor referring the patient to the BEC and confirmed during the preliminary interview at the BEC
•The patient is euthymic on the day of inclusion. This is supported by a short psychiatric interview conducted at the BEC and the completion of the depression and mania scales (score \<= 7 on the HDRS questionnaire and score \<= 7 on the YMRS questionnaire).
•The patient is prescribed a mood stabilizer based on lithium or divalproex.
•The patients withdraws consent during the study
•The patient does not understand directions necessary for the neurpsychological tasks
•The patient is not able to use a computer to complete the neuropsychological tasks

Exclusion Criteria

•The patient is under judicial protection, under tutorship or curatorship
•The patient formalizes his/her opposition to the studyd
•It is impossible to correctly inform the patient
•The patient has mental retardation
•The patient has practiced substance abuse or dependence within the 6 months prior to study inclusion (alcool, cannabis, opiates, psychostimulants)
•The patient does not meet euthymic criteria (score \<= 7 on the HDRS questionnaire and score \<= 7 on the YMRS questionnaire).

Key Dates

Start Date

January 1, 2017

Primary Completion Date

July 1, 2018

Completion Date

July 1, 2018

Last Updated

May 24, 2016

Conditions

Bipolar Disorder

Interventions

Interview

OTHER

Neuropsychological testing

OTHER

Serum concentration of lithium or sodium divalproate.

BIOLOGICAL

University of Iowa Interventional Psychiatry Service Patient Registry

NCT04480918

Treatment Resistant DepressionMajor Depressive Episode+5 more

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RECRUITINGPHASE3

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

NCT07140913

ManiaBipolar Disorder

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 24, 2016Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Neuropsychological Characterization of Patients With Bipolar Disorder and a History of Suicide Attempt

Inclusion Criteria

Exclusion Criteria

University of Iowa Interventional Psychiatry Service Patient Registry

A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

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