Males

Females who are pregnant or nursing.

Patients with other primary cancers requiring systemic treatment.

Patients with any metastatic disease.

Patients undergoing neoadjuvant endocrine therapy.

Patients with known hypersensitivity or allergy to any component of Definity.

Patients with cardiac shunts or congenital heart defects.

Patients with unstable cardiopulmonary conditions or respiratory distress syndrome.

Patients with uncontrollable emphysema, pulmonary vasculitis, pulmonary hypertension or a history of pulmonary emboli.

Patients who have received any contrast medium (X-ray, MRI, CT or US) in the 24 hours prior to the research US exam.

Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy