* Postmenopausal, defined as 12 consecutive months with no menses without an alternative medical cause.
* Of the two contraceptive methods that must be used, one must be from Group 1, and one must be from Group 2, defined as follows:
* Group 1: Oral, implantable, transdermal or injectable hormonal contraceptives, intrauterine devices, female sterilization (tubal ligation or non-surgical sterilization, e.g., permanent contraception with Essure procedure), or partner's sterilization (vasectomy). If a hormonal contraceptive is chosen from this group, it must be taken for at least one month prior to enrollment. Alternatively, if the Essure procedure is chosen as a contraceptive method, a hysterosalpingogram must have been performed to confirm correct location of the microinserts and tubal occlusion (as per manufacturer's recommendations).
* Group 2: Female or male condoms, diaphragm or cervical cap, any of them in combination with a spermicide.
* Sexual abstinence, rhythm methods, or contraception by the partner alone are not considered as acceptable methods of contraception for this study.
You may not be if
1. Patients who prematurely discontinued study drug in study AC-055-310.
2. Females who are lactating or pregnant (positive Visit 1 pregnancy test) or plan to become pregnant during the study.
3. AST and/or ALT more than 3 X ULN.
Clareo Health | Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH
