Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Washington
With
National Multiple Sclerosis Society
Age
18–59
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
English as primary language.
At least 9th grade education.
Physician confirmed, clinically definite MS diagnosis as defined by the revised McDonald criteria.
All MS subtypes will be included.
MS diagnosis at least 6 months prior.
Impaired speed of information processing and working memory based on either the PASAT-3" or the SDMT (i.e. z \<-1.5 controlling for age, education and sex).
Physician clearance to engage in aerobic exercise training.
Able to walk at least 100 meters without assistance (Expanded Disability Severity Scale score equivalent 0-5.5).
Currently exercising less than public health recommendations (engaging in less than 30 minutes of structured physical activity less than 3 times per week during the past 6 months).
Willingness not to undertake additional structured exercise or leisure time physical activity during the 6-month trial.
Willing and able to participate in either exercise training program 3 days per week for 6 months at a YMCA in the Greater Seattle Area.
You may not be if
Near visual acuity with correction 20/70 or worse.
Contra-indications for exercise training based on American Heart Association (AHA)/ACSM screening criteria using PAR-Q.
Using any medication known to have adverse effects on motor or cognitive function, including monoamine oxidase inhibitors, sympathomimetics, antipsychotic agents, modafinil, oxybutynin, tricyclic antidepressants, cholinesterase inhibitors and anticonvulsants other than gabapentin and pregabalin. The following are permitted if the patient has been on a stable dose for at least 6 weeks: short acting benzodiazepines (qhs administration only), anti-spasmodics, selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors.
Received steroids in last 30 days.
Relapse in the last 90 days.
Undergone neuropsychological testing within the past 6-months.
Neurological/psychological disease other than MS that may impact cognitive status, e.g. Alzheimer's disease, Parkinson's, stroke, TIA, Vascular Dementia, Huntington's, traumatic brain injury or chronic CNS infection.
Dementia based on a definition validated in people with MS using the MACFIMS (\> 2 SD below the mean on at least one memory test and \> 2 SD below the mean on at least one neuropsychological test in another domain).
Prior history of diagnosis or treatment for serious mental illness (obsessive-compulsive disorder, schizophrenia, other psychotic disorders, bipolar disorder).
Diagnosis of major depressive disorder prior to the diagnosis of MS.
History of significant developmental or learning disorder that may affect participation and confound interpretation of study results.
Current major depressive disorder.
Current alcohol or other drug abuse as measured by the WHO Alcohol, Smoking and Substance Involvement Screening Test (WHO ASSIST V3.0).
Clareo Health | Study of Exercise on Impact of Cognitive Functioning in Multiple Sclerosis Patients
