Protective Role of Oxcarbazepine in Multiple Sclerosis

Exclusion Criteria

• •Pregnant or breastfeeding or unwilling to use adequate contraception.\*
• •Participants with a diagnosis of primary progressive PP MS or primary relapsing PR MS.
• •A clinical relapse or pulsed intravenous or oral steroids in the 6 months preceding the baseline assessment.
• •Participants presenting with medical disorder deemed severe or unstable by the CI such as poorly controlled diabetes or arterial hypertension, severe cardiac insufficiency, unstable ischemic heart disease, abnormal liver function tests (\>2.5 times ULN) and abnormal complete blood count (in particular leukopenia, as defined by a lymphocyte count \<500, neutrophil count \<1.5 or platelet count \<100, or thrombocytopenia \<1.5 LLN), or any medical condition which, in the opinion of the investigator, would pose additional risk to the participant.
• •Infection with hepatitis B or hepatitis C or human immunodeficiency virus.
• •Exposure to any other investigational drug within 30 days of enrolment in the study.
• •Judged clinically to have a suicidal risk in the opinion of the investigator based upon a clinical interview and the Columbia Suicide-Severity Rating Scale (CSSRS).
• •Prior history of malignancy unless an exception is granted by the Investigator.
• •History of uncontrolled drug or alcohol abuse within 6 months prior to screening.
• •Past untoward reactions to OxCbz or Cbz
• •Participants receiving OxCbz or Cbz in the previous 12 weeks from baseline
• •* \[Adequate methods of contraception are non hormonal methods such as barrier methods, intrauterine devices, surgical sterilisation (undergone by the participant or their partner). Female participants using hormonal only forms of contraception will be required to use an additional barrier method. True abstinence can be considered an acceptable method of contraception when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods), declaration of abstinence for the duration of a trial, and withdrawal are not acceptable methods of contraception. Non sexually active participants or those in same sex relationships will not be required to commence contraception.\]