Drug Interaction Study With Rosuvastatin

Exclusion Criteria

• •Any significant acute or chronic medical illness
• •Current or recent (within 3 months of study drug administration) gastrointestinal disease
• •Any major surgery within 4 weeks of study drug administration
• •Any gastrointestinal surgery (eg, partial gastrectomy, pyloroplasty) including cholecystectomy that could impact upon the absorption of study drug
• •Donation of \> 400 mL of blood within 8 weeks or donation of plasma (except at screening visit) within 4 weeks of study drug administration
• •Blood transfusion within 4 weeks of study drug administration
• •Inability to tolerate oral medication
• •Inability to be venipunctured and/or tolerate venous access as determined by the investigator
• •Use of tobacco-containing or nicotine containing products (including but not limited to cigarettes, pipes, cigars, chewing tobacco, nicotine patches, nicotine lozenges, or nicotine gum) within 6 months prior to check-in, or a positive nicotine test (ie, cotinine) at screening or check-in
• •Subjects who drink more than 3 cups of coffee or other caffeine containing products with an equivalent amount of caffeine per day, or 5 cups of tea per day
• •History of allergy to Lysophosphatidic acid (LPA1) antagonists or related compounds