Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Kansas Medical Center
Research has suggested that high levels of erythropoietin (EPO) decreases the ability of infused umbilical cord stem cells to home to the bone marrow. The investigators will investigate the use of hyperbaric oxygen (HBO) therapy to decrease the plasma concentrations of EPO prior to UBC transplant and evaluate the resulting impact on UBC homing.
Age
17–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Voluntary written informed consent
Subjects must be \>/= 17 yrs and \</= 70 yrs for non-myeloablative transplant
Subjects must be \>/= 17 yrs and \</= 55 yrs for myeloablative transplant
Subjects with Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Myelodysplastic Syndrome (MDS), Hodgkin's Lymphoma (HL) and Non-Hodgkin's Lymphoma (NHL) who are considered for UCB transplant
Use of approved form of contraception
Karnofsky performance status of \>/= 70%
Adequate hepatic, renal, pulmonary and cardiac function. Criteria include:
ALT (alanine aminotransferase), AST (aspartate aminotransferase: \< 4x IULN (institutional upper limit of normal)
Total bilirubin \</= 2 mg/dL
Serum creatinine \< 2.0 mg/dL
Left ventricular ejection fraction \>/= 45%
FEV1 (forced expiratory volume), FVC (forced vital capacity) and DLCD (diffusing capacity of lung for carbon monoxide) \>/= 50% of predicted value (corrected to serum hemoglobin)
You may not be if
Pregnancy or breast feeding
Severe chronic obstructive pulmonary disease requiring oxygen supplementation
History of spontaneous pneumothorax
History of seizures
Claustrophobia
Asthma
Uncontrolled viral or bacterial infection at the time of enrollment
Active or recent (prior 6 months) invasive fungal infection without interdisciplinary consult and approval
