Feasibility of Lifestyle Intervention in BRCA1/2 Mutation Carriers

Exclusion Criteria

• •metastatic tumor disease
• •life expectancy \<3 years
• •clinically limiting cardiovascular or respiratory disease
• •significant orthopedic disability which prevents from participating in the exercise training
• •severe concomitant disease which prevents from participating in the group interventions
• •Karnofsky index \<60
• •VO2max \>150%
• •Maximal exercise capacity \< 50 W
• •food allergies which prevent from mediterranean diet
• •vegan diet
• •body mass index \<15 kg/m2
• •pregnancy
• •insufficient knowledge of German language
• •insufficient compliance
• •active participation in other interventional trials
• •no informed consent