Multidomain Intervention to Prevent Disability in Elders

Exclusion Criteria

• •Failure to provide informed consent;
• •Inability to complete a 400-meter walk test (primary outcome of the study);
• •Living in nursing home;
• •Living outside of the area of interest, or planning to move out of the area in next 3 years, or planning to leave the area for more than 3 months during the next year;
• •Relevant cognitive impairment (defined as a known diagnosis of dementia);
• •Severe progressive, degenerative neurologic disease (e.g., multiple sclerosis);
• •Severe rheumatologic or orthopaedic diseases (e.g., awaiting joint replacement);
• •Terminal illness with life expectancy less than 12 months;
• •Severe pulmonary disease (e.g., oxygen therapy or chronic use of steroids);
• •Severe cardiac disease (e.g., New York Heart Association Class III or IV heart failure, clinically significant aortic stenosis, history of cardiac arrest, uncontrolled angina);
• •Other significant comorbid conditions that would impair the ability to participate in the multidomain intervention (e.g., renal failure on hemodialysis, severe psychiatric disorder, excessive alcohol use). To be noted: persons with depression will not be excluded.