Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes

Exclusion Criteria

• •History of chronic infectious disease such as HIV or hepatitis
• •History of tuberculosis, TB risk factors, positive interferon-gamma release assay (IGRA, also known as the T-SPOT.TB test), or BCG vaccination
• •Current treatment with glucocorticoids (other than intermittent nasal or eye steroids), or disease or condition likely to require steroid therapy
• •Other conditions or treatments associated with increased risk of infections such as patients with a previous history of severe burns, or treatment with immunosuppressive medications of any type (e.g. imuran, methotrexate, cyclosporine, etanercept, infliximab) for any reason
• •Current treatment with aspirin \> 160 mg/day or chronic, daily NSAIDs
• •Current treatment with antibiotics
• •History of keloid formation
• •Average HbA1c over the past 5 years (or since diagnosis if duration is less than 5 years) \<6.5 or \> 8.5%
• •History or evidence of chronic kidney disease (serum creatinine \> 1.5mg/dL)
• •History of proliferative diabetic retinopathy that has not been treated with laser therapy
• •History of neuropathy, foot ulcers, amputations, or kidney disease
• •Pregnant or not using acceptable birth control
• •Living with someone who is immunosuppressed and/or at high risk for infectious diseases (for example HIV+ or taking immunosuppressive medications for any reason)