Advanced MRI Applications for Mild Traumatic Brain Injury

Exclusion Criteria

• •Subjects will be excluded that have:
• •1. Loss of consciousness (LOC) ≥15 minutes;
• •2. Posttraumatic amnesia lasting ≥24 hr following a recent TBI event;
• •3. Diagnosis of moderate to severe TBI or GCS \<13;
• •4. Structural brain injury indicated by previous neuroimaging findings;
• •5. Previous history of moderate to severe TBI;
• •6. Any previous history of mild TBI within the past 12 months;
• •7. Previously diagnosed brain white matter disease;
• •8. History of seizures within the past 10 years;
• •9. History of self-reported illicit drug abuse (except marijuana) in past 10 years;
• •10. History of alcohol abuse or dependence (per DSM-IV-TR Diagnostic Criteria);
• •11. Current primary Axis I or II psychiatric disorders, except for disorders classified as minor and not expected to impact study conduct or integrity (as detailed in Appendix D - Screening for Exclusion based on Axis I or II Disorders):
• •12. History of brain mass
• •13. History of neurosurgery
• •14. History of stroke
• •15. History of dementia
• •16. Known cognitive dysfunction
• •17. Known structural brain disease or malformation
• •18. Current anti-psychotic or antiepileptic medication usage
• •19. That are unable or unwilling to complete study procedures accurately or have any conflict of interest that could affect study results, in the opinion of the investigator;
• •20. Contraindications to MRI scanning, including:
• •1. Current or suspected pregnancy per site clinical practice;
• •2. Other conditions that may constitute a hazard to the subject during study participation, determined by the investigator;
• •3. Inability to comply with any part of the site's MR safety policy.
• •Subjects will be excluded that:
• •1. Are currently pregnant based on subject self-report of pregnancy status;
• •2. Are currently enrolled in another Segment of this study;
• •3. Require medical care that would be adversely affected or delayed by participating, in the opinion of a physician investigator;
• •4. Prior diagnosis of mild TBI within the past 12 months;
• •5. Have structural brain injury indicated by previous neuroimaging findings;
• •6. Previous history of moderate to severe TBI within the past 10 years;
• •7. Previously diagnosed brain white matter disease;
• •8. History of seizures within the past 10 years;
• •9. History of illicit drug abuse (except marijuana) within the past 10 years
• •10. History of alcohol abuse or dependence (per DSM-IV-TR Diagnostic Criteria);
• •11. Current primary Axis I or II psychiatric disorders, except for disorders classified as minor and not expected to impact study conduct or integrity (as detailed in Appendix D - Screening for Exclusion based on Axis I or II Disorders):
• •12. History of brain mass;
• •13. History of neurosurgery;
• •14. History of stroke;
• •15. History of dementia;
• •16. Known cognitive dysfunction;