Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Merck Sharp & Dohme LLC
Age
55–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Meets listed criteria for a diagnosis of probable AD
Has a clearly documented history either in medical records or from an informant of cognitive decline over at least 6 months
Has a reliable partner/caregiver who is willing to provide input by participating in assessments
Has results of a physical examination and clinical laboratory tests within normal or clinically acceptable limits
Can communicate with trial staff acceptably, possesses the ability to respond verbally to questions, follow instructions, complete questionnaires, and adhere to visit schedules
Can read at a 9th grade level or equivalent, and has an acceptable history of academic achievement and/or employment
Has a magnetic resonance imaging (MRI) scan that rules out non-AD conditions contributing to cognitive dysfunction
Capably performs the CogState screening battery
Has adequate visual acuity and function
Females are not of childbearing potential
You may not be if
Has ever received acetylcholinesterase inhibitors, memantine, or other symptomatic AD treatment including approved medical foods
Has an uncontrolled, clinically significant medical condition or situation within 3 months prior to screening
Has had major surgery within 3 months prior to screening
Has tested positive for human immunodeficiency virus (HIV) or has evidence of an active hepatitis B infection
Has a history of malignancy within the prior 5 years
Is unwilling or ineligible to undergo an MRI scan
Has a history of clinically important structural changes on screening MRI scan
Has a clinically important history of stroke or a diagnosis of vascular dementia
Has evidence of a clinically relevant non-AD neurological disorder
Has a history of head trauma, or serious infectious disease affecting the brain within the prior 3-5 years
Has evidence of a clinically relevant or unstable psychiatric disorder, excepting major depression in remission
Has evidence of a current episode of major depression
Has evidence of Type 4 or Type 5 Suicidal Ideation
Has clinically significant vitamin B12 or folate deficiency in the 6 months prior to screening
Is pregnant, attempting to become pregnant or is nursing children
Has used any investigational drug or participated in any other clinical trial within the prior 30 days
Has a history of alcoholism or drug dependency/abuse within the last 5 years
Has a relative contraindication to donepezil including sick sinus syndrome, third degree heart block, active gastrointestinal (GI) bleeding, Zollinger-Ellison syndrome, uncontrolled peptic ulcer disease, or uncontrolled asthma
