Presence of diarrhea attributed to any condition other than carcinoid syndrome.

Presence of 12 or more watery bowel movements per day

Positive stool examination for enteric pathogens, pathogenic ova or parasites, of Clostridium difficile at Screening

Karnofsky Performance Status ≤ 60%

Presence of any clinically significant laboratory, medical history, or physical examination findings deemed unacceptable by the Investigator

A history of short bowel syndrome

History of constipation within 2 years of Screening

Life expectancy \< 12 months from Screening

Telotristat Etiprate for Carcinoid Syndrome Therapy