PET Imaging of the Translocator Proteine Ligands (TSPO) With [18 F] DPA-714 Biomarker of NeuroInflammation in Cognitive Decline (NIDECO)

You may be eligible if

• Criteria common to all participants:
• Signed informed consent
• Age ≥ 60 years old (60-80 years old)
• Native language: French
• Correct sensory abilities (hearing aids accepted) to perform the tests
• Affiliated to a social security system
• Criteria for patients with mild to moderate Alzheimer disease defined according to the NINCDS-ADRDA {McKhann, 2011 # 408}:
• MMS between 20 and 25
• contraindication for MRI
• Criteria for amnestic MCI patients:
• Amnestic mildcognitive disorder evoking a MA in pre stage dementia {Dubois, 2010 # 273, Dubois, 2007 # 42; Pertersen, 1999 # 21, Albert, 2011 # 409} older than 60 years.
• Criteria for patients with isolated memory Complaint (Without Cognitive Decline):
• MMS score ≥ 26
• Normal performance by age and educational level
• medical history of evolutive disease with conséquences on NCS, chronic alcohol intake, severe depression with MADRS stage \> 18
• MA subjects : antagonistic treatment with N-methyl-D-aspartate
• MA or MCI subjects : anomaly on neurologic clinical examination different of the usual symptomatology