Biomarker Correlates of Hypoxia in Metastatic Melanoma

Inclusion Criteria

• •Must be 18 years or older with a histological diagnosis of locally advanced, recurrent or metastatic melanoma and be scheduled for clinically indicated surgical removal of one or more melanoma tumors. Additionally, patients must have a resectable tumor nodule ≥1 cm\^3 (i.e., either a spherical tumor at least 1.0 cm in diameter or a tumor measuring at least 1x1x1 cm). Prior biopsy is not required for study participation.
• •Not pregnant or nursing (as confirmed by serum pregnancy test if the patient is a woman of child-bearing potential). Participants must agree with use birth control for 30 days following pimonidazole administration.
• •Adequate kidney and liver function as assessed by laboratory studies
• •Must be able to undergo magnetic resonance imaging (MRI) scans
• •Capable of providing informed consent and demonstrate a willingness to comply with all the study procedures and visits
• •Eastern Cooperative Oncology Group (ECOG) score of 0 -1