PAH with surgical repair (at least 5 years previously) of atrial septal defect (ASD),ventricular septal defect (VSD), patent ductus arteriosus (PDA) and aorto-pulmonary window
PAH diagnosis confirmed by right heart catheterization performed within 12 months prior to randomization
Functional Class II-IV; Baseline 6MWD ≥ 50 m.
You may not be if
Significant (ie, \>2+) valvular disease other than tricuspid regurgitation or pulmonary regurgitation
History of cardiac arrest, respiratory arrest, hemodynamic collapse, CPR, ventricular tachycardia, ventricular fibrillation, or uncontrolled atrial fibrillation
History of pulmonary embolism; History of chronic lung disease / restrictive lung disease (eg, chronic obstructive pulmonary disease (COPD) or scleroderma) with impairment of lung function
No prior long term treatment with PDE-5 inhibitors
Treatment with bosentan OR riociguat within 3 months of randomization
Current treatment with nitrates or nitric oxide
Clareo Health | Effects of Oral Sildenafil on Mortality in Adults With PAH
