Tocotrienols and Bone Health of Postmenopausal Women

Exclusion Criteria

• •1. History of, or evidence for, metabolic bone disease including recent fractures (other than low BMD).
• •2. Having received medication (calcitonin, raloxifene, or systemic glucocorticoids) within 3 months before the start of the study.
• •3. Having bisphosphonate within 12 months before the start of the study.
• •4. Having hormone/hormone-like replacement therapy within 3 months before the initiation of the study.
• •5. History of cancer except for treated superficial basal or squamous cell carcinoma of the skin.
• •6. History or evidence of endocrine disease or malabsorption syndrome that would be a contraindication to the investigation of tocotrienols' absorption.
• •7. Uncontrolled diabetes mellitus defined by an HbA1c of ≥ 7% in the last 3 months.
• •8. History of statin or other drug for cholesterol-control within 3 months before the start of the study.
• •9. Alcohol intake greater than "moderate" (one drink per day) or use of nonsteroidal anti-inflammatory drugs on a regular basis.
• •10. Cognitive impairment, depression or other medical/eating disorders, likely to move during the trial, lack of transportation, distance from the study site, or unavailable at sample collection times.
• •11. Smoking \> 10 cigarettes/day.
• •12. Unwilling to accept randomization.