POSITIVE - Study (Part III) Heidelberg

Exclusion Criteria

• •serious active infection (i.e. requiring an iv antibiotic, antifungal or antiviral agent)
• •inability to walk
• •immobility (more than two days)
• •previously untreated (non-irradiated or non-resected) symptomatic brain metastases;permitted are: (1) previously treated brain metastases \[radiotherapy, surgery, dexamethasone dosage 8 mg per day, anti-epileptic therapy\]; (2) asymptomatic brain metastases without additional therapy requirement
• •severe neurologic impairment (e.g. apoplectic insult, Morbus Parkinson, pareses of extremities)
• •severe cardiac impairment (e.g. cardiac insufficiency NYHA (New York Heart Association) \> III, myocardial infarction within the last three months, unexplained syncopal events, severe cardiac arrhythmias, high grade aortic stenosis)
• •severe respiratory insufficiency
• •uncontrolled pain
• •abuse of alcohol or drugs reducing compliance to the study
• •bone metastasis inducing skeletal fragility
• •any circumstance that would impede ability to give informed consent or adherence to study requirements.