Pilot Study: Gene Expression Profiling of Immune Response to HBV Vaccination in Healthy Volunteers

Exclusion Criteria

• •Male or female \< 18 and \> 60 years of age
• •Received any vaccine within a month prior to study vaccine
• •History of Hepatitis B infection
• •History of previous Hepatitis B vaccination(s)
• •History of Hepatitis C virus (HCV) infection or positive HCV antibody test
• •Participation in another clinical study of an investigational product currently or within the past 90 days, or expected participation during this study
• •Positive serum antibody against Hep B surface antigen and/or core Hep B core antigen
• •human immunodeficiency virus (HIV) positive
• •In the opinion of the investigator, the volunteer is unlikely to comply with the study protocol
• •Any clinically significant abnormality or medical history or physical examination including history of immunodeficiency or autoimmune disease
• •Is pregnant or lactating
• •Currently taking systemic steroids or other immunomodulatory medications including anticancer medications and antiviral medications
• •Any clinically significant acute or chronic medical condition requiring care by a primary care provider (e.g., diabetes, coronary artery disease, rheumatologic illness, malignancy, substance abuse) that, in the opinion of the investigator, would preclude participation
• •Unable to continue participation for 30 weeks