1. Age \< 18 years

2. Clinical prediction that the patient will not survive at least 48 hours

3. Acute bleeding: \> 2 units of packed red blood cells/hour

4. Vasopressor use: noradrenalin \> 0.2 μg/kg/min or any use of adrenalin within 6 hours of inclusion into the study

5. Therapy with inhaled NO, inhaled prostacyclin, or phosphodiesterase-5-inhibitors

6. Sepsis

Hemodynamic Effects of Stored Blood Transfusion in Intensive Care Patients