A New Oral salIvary equivAlent Compared to Two moisturizinG Mouth sprAys in Patients With xeRostomiA: NIAGARA Study

Inclusion Criteria

• •Patients:
• •Aged 18 years or more,
• •Clinical diagnosis of xerostomia by a severe reduction of salivation, as detected by patient's answers to few specific questions and measured by saliva volume at screening visit (test of saliva weight absorbed ≤ 0.1g/min)
• •Any medical condition or treatment leading to a severe reduction of salivation related to either:
• •Head and neck radiation therapy for cancer,
• •Gougerot-Sjögren syndrome
• •Medications known to induce xerostomia (psychotropic drugs, antihypertensive drugs)
• •Dehydration, hypothyroidism, Parkinson's disease and/or diabetes mellitus
• •Female patients must be post-menopausal or using a highly effective method for avoidance of pregnancy throughout the whole study duration, if childbearing potential.
• •Able to understand and comply with the protocol procedures
• •Willing and able to give their written informed consent
• •Affiliated to the French National Health Insurance Program