1. Prior treatment with ANG1005/GRN1005

2. Evidence of symptomatic intracranial hemorrhage

3. Pregnancy or lactation

4. Inadequate bone marrow reserve

5. Any evidence of severe or uncontrolled diseases

6. Patients with the presence of an infection including abscess or fistulae, or known infection with hepatitis B or C or HIV

7. History of interstitial lung disease or evidence of clinically significant interstitial lung disease

8. Severe cardiac conduction disturbance

9. Central nervous system (CNS) disease requiring immediate neurosurgery intervention

10. Known severe hypersensitivity or allergy to paclitaxel or any of its components

ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases