1. materials 1) inclusion criteria
1. over 18-year-old
2. patients with myeloablative conditioning regimen
3. autologous transplant
4. patients with confirmation of acute GVHD as over grade II
5. patients with salvage chemotherapy
2\) exclusion criteria
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1. old age ( over 60-year-old)
2. patients with reduced intensity stem cell transplantation
2. method 1) check the serum level of HMGB1, TNF-a, IL-1b, IL-6, Th1, Th2, Th17, FoxP3 on 7-day before transplant day(D-7), transplant day(D0), 7-day after transplant(D+7), D+14, D+21. 2) check the immunohistochemistry level of tissue in diagnosed aGVHD ( performed sigmoidoscopy and random biopsy of gut is routine process in our center) 3) check the oral mucositis grades (using WHO grading system, NCI -CTC ver.3 scoring system)
3. analysis 1) student t-test , chi-square test 2) survival analysis
