Obese males and females: age \>20 years; Obese population defined as BMI \> or = 27 kg/m2
Lean population BMI \< 27 but \> 17 kg/m2
Able and willing to provide written informed consent for the trial
You may not be if
Evidence of inherited disorders of lipid metabolism.
History of Cancer within the last 5 years
Human immunodeficiency virus (HIV) antibody positive.
Patients with solid organ transplants.
Participation in any other clinical trial within 90 days of entry into this trial.
Pregnant or lactating females.
Uncontrolled thyroid disease
Unstable angina or NY heart association class II failure or above
Gastrointestinal disease specifically GI motility disorders
Unstable neuropsychiatric disease including major depression/anxiety, eating disorder such as binge eating, bulimia or anorexia
End stage renal or hepatic disease
Autoimmune disorders (e.g. SLE)
Body weight fluctuation of more than 5 kg in the previous 3 months
Prior bariatric surgery
A history or current alcohol/substance abuse and change in smoking habits or cessation in the past 6 months.
Women of childbearing age must use a reliable form of contraception.
Any medical condition, which in the opinion of the investigator would make the patient unsuitable for recruitment, or could interfere with the patient participating in or completing the protocol.
Unwilling or unable to consent for the study.
Clareo Health | Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance