Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism

Exclusion Criteria

• •1. type 1 Diabetes
• •2. Type II Diabetes
• •3. Impaired renal function
• •4. Prior allergies to medications used in the study protocol
• •5. Screening plasma potassium \>5.5 mmol/L or sodium \<135 mmol/L
• •6. Cardiovascular disease
• •7. Use of hormone replacement therapy
• •8. Breast-feeding
• •9. Treatment with anticoagulants
• •10. History of serious neurologic disease
• •11. History or presence of immunological or hematological disorders
• •12. Diagnosis of asthma requiring use of inhaled beta agonist
• •13. Clinically significant gastrointestinal impairment
• •14. Impaired hepatic function
• •15. Hematocrit \<35%
• •16. Any underlying or acute disease requiring regular medication which could possibly pose a threat to the subject or make implementation of the protocol or interpretation of the study results difficult, such as arthritis treated with non-steroidal antiinflammatory drugs
• •17. Treatment with chronic systemic glucocorticoid therapy
• •18. Treatment with lithium salts
• •19. History of alcohol or drug abuse
• •20. Treatment with any investigational drug in the 1 month preceding
• •21. Mental conditions rendering the subject unable to understand the nature, scope and possible consequences of the study
• •22. Inability to comply with the protocol, e.g., uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study