The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives

Exclusion Criteria

• •A clinically significant medical condition which could impact the response of the individual to antidepressant treatment (e.g. diabetes, cancer, lupus or other autoimmune illness). Stably treated hypothyroidism (TSH \< 2) will be permitted.
• •Beta blockers, antidepressants, antipsychotics, lithium, antiepileptic medications, steroids (oral and inhaled), chronic use of nonsteroidal antinflamatory medications (infrequent sporadic use permitted), or other medications with the potential to interfere with the antidepressant effects of Vilazodone.
• •Pregnancy.
• •In women of childbearing potential an unwillingness to use reliable methods to prevent pregnancy.
• •History of manic or psychotic symptoms.
• •History of seizure or epilepsy.
• •History of alcohol or drug dependence and active use of substances in the past month.
• •Active alcohol or drug abuse.
• •Ingestion of 4 or more caffeinated beverages a day, on average.