Study of Efficacy and Safety of Brodalumab in Subjects With Psoriatic Arthritis

Exclusion Criteria

• •-Subject has known history of active tuberculosis.
• •Subject has a planned surgical intervention between baseline and the week 52 evaluation.
• •Subject has an active infection or history of infections.
• •Subject has any systemic disease (eg, renal failure, heart failure, hypertension, liver disease, diabetes, anemia) considered by the Investigator to be clinically significant and uncontrolled.
• •Subject has any concurrent medical condition or electrocardiogram (ECG) abnormality that, in the opinion of the investigator, could cause this study to be detrimental to the subject.
• •Subject has severe depression measured by Personal Health Questionnaire Depression Scale (PHQ-8) or suicidal ideation/behavior as measured by and Columbia Suicide Severity Rating Scale (e-CSSRS)
• •Subject has a history or evidence of psychiatric disorder or substance abuse considered by the Investigator to pose a risk to subject safety