Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension

Baseline systemic hypotension, defined as MAP less than 50 mmHg

Required intravenous inotropes within 30 days prior to study participation

Has uncontrolled systemic hypertension as evidenced by sitting systolic blood pressure \>160 mm Hg or sitting diastolic blood pressure \>100 mm Hg at screening

Has a history of portal hypertension or chronic liver disease, including cirrhosis, chronic alcoholism, hepatitis B and/or hepatitis C (with evidence of recent infection and/or active virus replication) defined as moderate to severe hepatic impairment (Child-Pugh Class B-C)

Has chronic renal insufficiency as defined by serum creatinine \>2.5 mg/dL at screening or requires dialysis support

Has a hemoglobin concentration \<9 g/dL at Screening

History of atrial septostomy

Repaired or unrepaired congenital heart disease (CHD)

Pericardial constriction

Restrictive or congestive cardiomyopathy

Left ventricular ejection fraction 40% by multiple gated acquisition scan (MUGA), angiography or echocardiography

Symptomatic coronary disease with demonstrable ischemia

Other severe acute or chronic medical or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study

Has a psychiatric, addictive or other disorder that compromises the ability to give informed consent for participating in this study. This includes subjects with a recent history of abusing alcohol or illicit drugs 30 days prior to study screening Day 1 and for the duration of the study

Poorly controlled asthma defined by active wheezing and/or cough with FEV1 \< 70% predicted, responsive to inhaled BD (\>15% increase in FEV1 with BD)

Clinically significant intercurrent illness (including lower respiratory tract infection) or clinically significant surgery within 4 weeks before the administration of study drug

History of hypersensitivity or idiosyncratic reaction to drugs from multiple drug classes

Receipt of an investigational product or device, or participation in a drug research study within a period of 15 days (or 5 half lives of the drug, whichever is longer) before the first dose of study drug

Blood loss or blood donation \>550mL within 90 days or plasma donation \>500 mL within 14 days before administration of study drug;

Patients with a QTc interval \> 450 msec

Has diabetes mellitus as defined by symptoms of hyperglycemia and serum fasting plasma glucose level≥7.0mmol/l or casual plasma glucose≥11.1mmol/l at screen

Has a hyperlipidemia as TC≥6.22 mmol/L, LDL-C ≥4.14 mmol/L or TG ≥2.26 mmol/L

History of crohn's disease, ulcerative colitis (UC) and etc. Inflammatory bowel disease (IBD)

Patients who are not willing to take contraceptive measures during the study

Patients who are taking certain other medication will need to be evaluated for possible exclusion based on the potential for adverse drug interactions

What this study is about