Pilot Study - Effect of Omega-3 on Systemic Lupus Erythematosus

Supplementation with EPA and DHA could potentially reduce the inflammatory state of SLE patients. This study is a single blind placebo-controlled pilot for SLE patients with 25 scheduled to receive omega-3 (EPA 2.25g/DHA 2.25g) daily and 25 scheduled to receive placebo (olive oil), for 6 months. Pre and post supplementation assessments will be made to determine if EPA and DHA levels increase, and if the levels of lipid peroxidation products, other cellular energy intermediates, and inflammatory markers are affected by EPA/DHA. Additionally, lupus disease activity, fatigue, quality of life, and diet will be assessed to determine if these parameters are related to the metabolome in SLE. * Aim 1: \- To determine if the metabolomic disturbances of lupus patients improve following supplementation with omega-3 fatty acids. * Aim 2: * To determine if lupus disease activity, fatigue, and quality of life improve and are related to the metabolomic profile changes.