Predictive Factors of Obesity-hypoventilation Syndrome (OHS) Among Obese Subjects- ETUDE COHYPOB -

NCT02021448•University Hospital, Strasbourg, France

Summary

Investigate whether the course of an isolated nocturnal alveolar hypoventilation can predict the future occurrence of obesity-hypoventilation syndrome (OHS) in obese subjects

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Obese volunteer Subject (BMI\> 30 kg/m2)
•Adults of either sex
•Social security affiliation
•Written informed consent

Exclusion Criteria

•Confirmed OHS at baseline defined by a daytime hypercapnia with PaCO2\> 45mmHg
•Any cause of chronic respiratory failure other than obesity such as COPD, chest deformation, phrenic nerve paralysis, pulmonary fibrosis, neuromuscular disease, a history of mutilating thoracic surgery ...
•Obstructive ventilatory defect with FEV1/ FVC \<70% post-bronchodilator
•Long term oxygen therapy, noninvasive ventilation, continuous positive airway pressure
•Any serious illness involving life-threatening within 3 years after inclusion
•Drug or alcohol abuse
•Pregnancy

Locations (6)

CHU Angers

Angers, France

CHU Brest

Brest, France

CH Cannes

Cannes, France

CHU Grenoble

Grenoble, France

CHU Reims

Reims, France

CHU Strasbourg

Strasbourg, France

Key Dates

Start Date

December 1, 2013

Primary Completion Date

January 1, 2022

Completion Date

June 1, 2022

Last Updated

July 11, 2022

Enrollment

188

ACTUAL participants

Conditions

Obesity-hypoventilation SyndromeNocturnal Alveolar Hypoventilation

Interventions

Annual visits among 3 years. During each visit different testings are performed in order to detect an obesity-hypoventilation syndrome (OHS)

OTHER

Resting Energy Expenditure in Patients With OHS Treated With Long-term NIV

NCT04474587

Obesity-hypoventilation SyndromeResting Energy Expenditure+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 11, 2022Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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