Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hoffmann-La Roche
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Males or females aged \>/= 18 years and \</= 60 years
Clinically stable, mild or moderate schizophrenia
On stable antipsychotic treatment for the last 6 months
Generally healthy in the investigator's opinion, based on assessment of medical history, physical examination, vital signs, electrocardiogram (ECG), and the results of the hematology, clinical chemistry, urinalysis, serology, and other laboratory tests
Willingness to be hospitalized for approximately 3 weeks
BMI \> 18.5 kg/m2 and \< 38 kg/m2
Use of highly effective contraception as defined by the study protocol. Men must also not donate sperm until at least 30 days after the last dose, and women cannot be pregnant or breastfeeding
You may not be if
Treatment with antiparkinson medication including anticholinergic drugs
Treatment with depot antipsychotic medication within the last three months prior to screening
Participation in a clinical trial with an investigational drug or device \< 3 months prior to screening
Smokes more than 20 cigarettes per day
Current drug abuse (excluding nicotine) or drug abuse within 3 months prior to the screening visit
Any donation of blood or significant blood loss within three months prior to first administration of the study drug
Use of prohibited medications (including vitamins or herbal remedies) taken within 14 days or within 5 times the elimination half-life of the medication (whichever is longer) before the first study drug administration
