Positioning and Gastric Aspiration in Ventilated Premature Infants

NCT02016651•Cairo University

Summary

Gastro-esophageal reflux and aspiration is a common problem in premature infants receiving mechanical ventilation. Pepsin measured in tracheal aspirate (TA) emerged as a specific marker for aspiration. The objective of this study is to examine if TA pepsin will change when ventilated premature infants are positioned in two different positions; on their back vs. on their right side.

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Infants born between 28 and 32 weeks gestational age
•postnatal age \> 72 hours
•tracheally intubated and receiving conventional mechanical ventilation
•feeding enterally more than 20 ml per day.

Exclusion Criteria

•neurological insult in the form of perinatal asphyxia (pH \<7, base deficit more than 12, Apgar score at \< 3 at 5 minutes of life), intracranial hemorrhage grades 3 or 4 at 72 hours of age or periventricular leucomalacia
•major congenital anomalies, or gastrointestinal anomalies such as tracheoesophageal fistula, or necrotizing enterocolitis ,
•receiving xanthine derivatives, H2 blockers, prokinetics, proton pump inhibitors or sedation

Locations (1)

Cairo University Children's Hospital

Cairo, Cairo Governorate, Egypt

Key Dates

Start Date

January 1, 2012

Primary Completion Date

July 1, 2013

Completion Date

December 1, 2013

Last Updated

December 20, 2013

Enrollment

ACTUAL participants

Conditions

Respiratory Aspiration of Gastric Contents

Interventions

Right side position

BEHAVIORAL

Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying

NCT07140289

Gastric EmptyingGlucagon-Like Peptide-1 Receptor Agonists+3 more

View study

COMPLETED

Fibreoptic Intubation With and Without Sellick´s Maneuver

NCT01357824

Intubation IntraesophagealRespiratory Aspiration of Gastric Contents

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 20, 2013Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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