Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Lille Catholic University
With
Bayer
The objective of the present study is to assess concordance between oligoclonal bands detection in tears and in cerebrospinal fluid. We will include patients with primary progressive multiple sclerosis and we will compare results of oligoclonal bands detection by isoelectric focusing in cerebrospinal fluid and tears. Tears will be collected using a Schirmer strip. This would circumvent the practice of invasive lumbar punctures currently used in multiple sclerosis diagnosis.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 years old or more
Progressive neurological deficit after 12 months
At least 9 T2 brain lesions of minimum 3 mm evidenced by MRI and/or four or more T2 lesions of minimum 3 mm with positive Visual Evoked Potential and/or positive spinal cord MRI (at least two focal T2 lesions)
You may not be if
Asiatic persons
recurrent forms of the disease
Persons wearing contact lenses
Ocular Infection
Corticoid treatment at least 30 days before sampling
immunosuppressive or immunomodulatory treatment 3 months before sampling
