Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents

Inclusion Criteria

• •A. Disease inclusions
• •1. Hematologic malignancy:
• •* Acute lymphoblastic leukemia including induction failure, CR1 (Ph+, t(4:11), hypodiploid and other very high risk features), ≥ CR2, infant ALL with MLL or other unfavorable features
• •* Acute myeloid leukemia excluding CR1 with t(8:21), inv(16), t(15:17), and Down syndrome
• •* Myelodysplastic syndrome: RCC with -7 or RCC in need of transfusion
• •* Chronic myeloid leukemia in AP
• •* Juvenile myelomonocytic leukemia
• •* Malignant lymphoma, NHL or HD, after failed autologous HSCT
• •* Other
• •2. Non-hematologic malignancy
• •* Relapsed or refractory solid tumors including neuroblastoma, rhabdomyosarcoma and so on
• •3. Non-malignant hematologic disease
• •* Acquired severe and very severe aplastic anemia
• •* Fanconi anemia
• •* Paroxysmal nocturnal hemoglobinuria
• •* Congenital dyserythropoietic anemia
• •* Others
• •4. Inherited or metabolic disease
• •* Hemophagocytic lymphohistiocytosis
• •* Malignant osteopetrosis
• •* Storage diseases
• •* Others B. Recipient inclusions
• •1\. Age \< 21 years 2. No HLA-identical stem cell donor available 3. Lansky-Play performance score \>60 4. No active infection at the time of transplantation