Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hoffmann-La Roche
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Histologically or cytologically documented, locally advanced or metastatic NSCLC.
Participants in Stage 1 (Safety Evaluation) receiving erlotinib: No limit to the number of prior therapies (except for EGFR TKIs).
Participants in Stage 2 (Expansion) receiving erlotinib: i) sensitizing mutation in the EGFR gene and ii) consent to collection of tumor tissue samples before, during, and after treatment for biopsy and PD biomarker analyses.
Participants receiving alectinib in either Stage 1 or Stage 2: must be ALK positive as assessed by Food and Drug Administration (FDA) approved test and must not have received prior treatment for their advanced NSCLC.
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Life expectancy of at least 12 weeks.
Measurable disease, as defined by RECIST Version 1.1 (v1.1).
Adequate hematologic and end-organ function.
Use of highly effective contraception (as defined by protocol) and until 5 months after the last dose of atezolizumab and for 3 months after the last dose of alectinib or for 2 weeks after the last dose of erlotinib, whichever is longer; Males must also refrain from sperm donatation during this same time period. Participants must not be pregnant or breastfeeding.
Archival tumor tissue specimen meeting protocol specifications or the participant will be offered the option of a pre-treatment biopsy to obtain adequate tissue sample.
You may not be if
For participants receiving erlotinib group: prior treatment with any EGFR mutant-targeting TKI
Any approved anticancer therapy, including chemotherapy, or hormonal therapy (except hormone-replacement therapy or oral contraceptives) within 3 weeks of first dose.
Treatment with any other test drug or participation in another clinical trial within 28 days of enrollment.
Known symptomatic central nervous system (CNS) metastases. Participants with a history of treated or untreated asymptomatic CNS metastases may be eligible.
Leptomeningeal disease.
Uncontrolled tumor-related pain.
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring drainage at least once monthly.
High levels of calcium requiring bisphosphonate therapy or denosumab.
Malignancies other than NSCLC within 5 years prior to enrollment, with the exception of those with a negligible risk of metastasis or death (such as adequately treated carcinoma in-situ of the cervix, basal or squamous cell skin cancer, localized prostate cancer, or ductal carcinoma in situ).
History of severe allergic, anaphylactic, or other reactions to chimeric or humanized antibodies or fusion proteins.
Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cells or any component of the atezolizumab formulation.
History of autoimmune disease.
Participants with prior bone marrow or solid organ transplantation.
History of lung inflammation or disease.
Serum albumin less than (\<) 2.5 grams per deciliter (g/dL).
Positive for Human Immunodeficiency Virus (HIV).
Liver disease.
Current or active tuberculosis, hepatitis B, or hepatitis C.
Participants with past or resolved hepatitis B virus (HBV) infection are eligible; participants positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV Riboxy Nucleic Acid (RNA).
Signs or symptoms of infection within 2 weeks prior to first dosing.
Received therapeutic oral or IV antibiotics within 2 weeks prior to first dosing.
Significant cardiovascular disease.
Major surgical procedure other than for diagnosis within 28 days prior to first dosing or during the course of the study.
Administration of a live, attenuated vaccine within 4 weeks before first dosing or during the study.
Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding that may reasonably prevent the participant from participating.
Hypersensitivity to erlotinib or alectinib or to any of the excipients.
Any significant ophthalmologic abnormality. The use of contact lenses is not recommended during the study.
For participants receiving alectinib: baseline Fridericias corrected QT interval (QTcF) greater than (\>) 470 milliseconds (ms) or symptomatic bradycardia.
Prior treatment with CD137 agonists or immune checkpoint blockade therapies.
Treatment with systemic immunostimulatory agents within 6 weeks or five half-lives of the drug, whichever is shorter, prior to first dosing.
Treatment with systemic immunosuppressive medications within 2 weeks prior to first dosing (inhaled corticosteroids and mineralocorticoids are allowed).
Participants who received acute, low-dose systemic immunosuppressant medication or a one-time pulse dose of systemic immunosuppressant medication are elgible for study after discussion and approval by the Medical Monitor.
Clareo Health | A Phase 1b Study of Atezolizumab in Combination With Erlotinib or Alectinib in Participants With Non-Small Cell Lung Cancer (NSCLC)
