Baclofen Effects on Marijuana Dependence

Exclusion Criteria

• •Participation in a clinical trial and receipt of investigational drug(s) during the previous 60 days.
• •Presence of magnetically active irremovable prosthetics, plates, pins, permanent retainer, bullets, etc. (unless a radiologist confirms that it's presence is unproblematic). An x-ray may be obtained to determine eligibility given the possibility of a foreign body.
• •Current use of non-removable medicated or nicotine skin patches.
• •Current or prior gambling problems (assessed by subject's self-report).
• •Current treatment for marijuana dependence.
• •Any other current drug dependence diagnoses (except nicotine dependence).
• •Any other psychiatric diagnoses. Current diagnosis/recent history (within past 6 months) of Major Depressive Disorder (MDD).
• •History of head trauma or injury causing loss of consciousness, lasting more than three (3) minutes or associated with skull fracture or inter-cranial bleeding or abnormal Magnetic Resonance Imaging (MRI).
• •Claustrophobia or other medical condition preventing subject from lying in the MRI for approximately one (1) hour.
• •Clinically significant cardiovascular, hematologic, hepatic (liver), renal (kidney), neurological, or endocrinological abnormalities, bloodwork, and/or electrocardiogram (EKG).
• •Uncontrolled diabetes or uncontrolled hypertension.
• •History of psychosis, seizures, or organic brain syndrome.
• •Vision problems that cannot be corrected with glasses.
• •Weight exceeding 300 pounds \[Imaging data acquisition is impaired with high weight individuals\].
• •History of stroke.
• •Case-by-Case:
• •Human immunodeficiency virus (HIV) positive on medication for symptoms. This will be determined on an individual basis by results from the physical examination and final approval by our study physician; all results from the physical within normal range for study inclusion.
• •Use of medications or natural herbs that cause sedation or affect the brain systems that are being studied. Medication use will be evaluated by our study physician on a case-by-case basis. For example, if the subject takes Benadryl but can safely refrain from use 24 hours prior to scanning sessions, they will not be excluded.
• •Significant history of past alcohol or substance abuse.