Study of Electrical Impedance Myography (EIM) in ALS

Inclusion Criteria

• •Sporadic or familial ALS (as defined by revised El Escorial criteria)
• •Onset of weakness or spasticity due to ALS ≤ 36 months prior to the Screening/Baseline Visit.
• •Slow vital capacity (SVC) ≥60% of predicted for gender, height, and age
• •\- Diagnosis of one of the following:
• •a. Pure Lower Motor Neuron Disease (LMND) mimics: i. Multi-focal motor neuropathy ii. Autoimmune motor neuropathy iii. Cervical or lumbosacral radiculopathies with weakness involving more than one extremity or more than a single myotome if restricted to one extremity.
• •iv. Multiple peripheral mononeuropathies with clinical weakness v. Charcot-Marie-Tooth Disease vi. Any condition that produces generalized or localized weakness without concomitant sensory symptoms, including myasthenia gravis or myopathy, that the evaluating physician deems mimics ALS.
• •b. Pure Upper Motor Neuron Disease (UMND) mimics: i. Cervical myelopathy ii. Multiple sclerosis iii. Hereditary spastic paraparesis
• •\- Absence of a known neurological disorder.