Venlafaxine PK Following Bariatric Surgery

Exclusion Criteria

• •1. Taking a medication that has a clinically significant interaction with venlafaxine or an interaction that may alter the study data.
• •2. Hypersensitivity to venlafaxine or any excipient contained within the dosage forms
• •3. Inability to tolerate repeated blood draws.
• •4. Any history of bipoloar disorder or a psychotic disorder.
• •5. Current major depressive disorder or current suicidality.
• •6. Alcohol or substance dependence in the past year.
• •7. Currently pregnant or lactating or unwillingness to use medically accepted contraception during study
• •8. Taking a medication which significantly alters gastrointesinal transit time or significantly reduces acid secretion (e.g. routine use of proton pump inhibitors, H2 antagonists, sucralfate).
• •9. Medical conditon which may increase participant risk with venlafaxine or uncontrolled hypertension at the discretion of the examining provider.
• •10. Hepatic insufficiency as defined by any hepatic enzyme greater than 3x the upper limit of normal or other hepatic laboratory abnormalities at the discretion of the medical provider.
• •11. Renal impairment as evidence by a calculated creatinine clearance of less than or equal to 70ml/min or other abnormality on a renal panel that the medical provider feels puts the participant at risk.
• •12. Poor or ultra-rapid Cytochrome P450 2D6 metabolizer.
• •13. Self reported history of viral hepatits or HIV.
• •14. Positive urine drug screen unless documented prescription of a non-interacting medication.