Erythromycin in Parkinson's Disease

Exclusion Criteria

• •History of deep brain stimulation for Parkinson Disease
• •History of ablative (tissue removal) surgery for Parkinson Disease
• •Presence of dementia (MMSE\<25)
• •Presence of active psychosis
• •History of any chronic gastrointestinal diseases
• •History of any prior gastrointestinal surgeries except for appendectomy, cholecystectomy, and hysterectomy
• •Any gastrointestinal surgeries in the past 3 months
• •Severe dysphagia (difficulty swallowing) to pills or food
• •History of physiological or mechanical gastrointestinal obstruction
• •History of strictures or fistulae (abnormal or narrow connections) along the gastrointestinal tract
• •History of gastric bezoars (undigested mass)
• •Allergy to wheat, soy, milk, or nuts
• •Presence of portable electromechanical devices such as pacemaker, defibrillator, or infusion pump
• •Female subjects who are pregnant or lactating
• •Symptomatic orthostatic hypotension (low blood pressure)
• •Diabetes
• •Presence of symptomatic anemia
• •Abnormal liver or kidney function
• •Cardiac arrhythmia (past or present) or abnormal QT interval on entrance EKG
• •Known hypersensitivity to any of the study drugs
• •Subjects receiving certain medications during specified time frames