Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Instituto Aragones de Ciencias de la Salud
With
Hospital Clinic of Barcelona
Instituto de Salud Carlos III
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age ≥18 years.
Diagnosis of Familial Combined Hyperlipidemia\* and Familial Hypercholesterolemia\*\*.
Body mass index \> 25 kg/m2.
Steady weight (±3 kg in the last 3 months).
Absence of lipid lowering drugs including sterols supplements in the previous 5 weeks.
* Familial Combined Hyperlipidemia diagnosis was based on the presence of primary combined hyperlipidaemia in untreated patients whose serum cholesterol and triglyceride concentrations were above the sex- and age-specific 90th percentiles for the Spanish population, serum total apolipoprotein B concentration ≥ 120 mg/dL and there was at least one first-degree relative with hyperlipidemia (total cholesterol and/or triglycerides \>90th percentile) (Gómez-Gerique JA et al; 1999).
* Familial Hypercholesterolemia was diagnosed in subjects with off-treatment LDL cholesterol concentrations above the age- and sex-specific 95th percentile of a Spanish reference population, triglyceride below 200 mg/dL and familial vertical transmission with at least one first-degree relative with LDL cholesterol above age- and sex-specific 95th percentiles (Gómez-Gerique JA et al; 1999).
You may not be if
Alcohol consumption \>30 gr/day.
Uncontrolled type-2 diabetes (HbA1c \>8%).
Any other disease that could interfere with the ability to comply with the study protocol were excluded
Personal history of cardiovascular disease, very high risk as defined by the presence of ≥ 2 major risk factors, or total cholesterol ≥ 350 mg/dL since lipid-lowering drug were considered highly recommended.
Clareo Health | Effect of Weight Loss on Cholesterol Metabolism in Hereditary Hypercholesterolemias and Overweight or Obesity.
