Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Exelixis
The goal of this clinical trial was to learn if the combination of the drugs cabozantinib and abiraterone works for men that were chemotherapy-naive, bone metastasis CRPC patients. It was designed to learn about the safety of cabozantinib. The main questions are:
1. Does it work and is it safe in men with chemotherapy-naïve bone- metastatic castration resistant CRPC?
2. What was the clinical benefit at different dose levels of the combination of abiraterone and cabozantinib in this patient population?
Participants were assigned to one of the four treatment groups:
Arm 1. cabozantinib at a dose of 40 mg every day (QD) plus abiraterone with prednisone; Arm 2. cabozantinib at a dose of 20 mg QD plus abiraterone with prednisone; Arm 3. cabozantinib at a dose of 20 mg every other day (QOD) plus abiraterone with prednisone; Arm 4. abiraterone with prednisone.
Age
18–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Histologically or cytologically confirmed adenocarcinoma of the prostate.
Must be surgically or medically castrated (serum testosterone levels less than or equal to 50 ng/dL)
Must have castration-resistant prostate cancer (CRPC) with disease progression during LHRH therapy or after a surgical bilateral orchiectomy.
Bone metastasis related to prostate cancer
Adequate organ and marrow function
Capable of understanding and complying with the protocol requirements and signed the informed consent document
Sexually active subjects and their partners must agree to use medically accepted methods of barrier contraception (eg, male condom or female condom) as well as one other medically accepted method of contraception during the course of the study treatment and for 4 months after the last dose of study treatment.
You may not be if
Any prior treatment with abiraterone, enzalutamide, or any investigational agents blocking androgen receptor (AR) or androgen synthesis.
Any prior treatment with cabozantinib or participation in a prior clinical trial of cabozantinib.
Any prior cytotoxic therapy (including estramustine) or biologic therapy for the treatment of prostate cancer (a few exceptions will be allowed)
Any prior radionuclide therapy (eg, samarium 153, strontium 89, alpharadin)
Use of investigational agent within 28 days
Any pathological finding consistent with small cell carcinoma of the prostate
Known brain metastases or cranial epidural disease
Diagnosis of another malignancy within 2 years, except for superficial non-melanoma skin cancers, or localized, low grade tumors deemed cured and not treated with systemic therapy
