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This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF), and/or changes in brain connectivity. The investigators will also examine whether different types of anesthesia have different effects on these CSF markers of Alzheimers disease, or different effects on thinking and memory after anesthesia and surgery, or differential effects on the correlation between cognitive changes and CSF marker changes.
Age
60 - No limit years
Sex
ALL
Healthy Volunteers
No
Duke University Medical Center
Durham, North Carolina, United States
Start Date
November 1, 2013
Primary Completion Date
January 10, 2019
Completion Date
January 10, 2019
Last Updated
March 22, 2023
191
ACTUAL participants
Total intravenous anesthesia with propofol
DRUG
General anesthesia with isoflurane
DRUG
Lead Sponsor
Duke University
NCT07170150
NCT07177352
NCT07323485
Data Source & Attribution
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