Multiplex Testing for Breast Cancer Susceptibility: A Pilot Study of Subject Preferences for Information and Responses After Testing

Inclusion Criteria

• •Male or Female age 18 or older
• •Personal history of breast cancer AND one of the following:
• •Invasive breast cancer or DCIS diagnosed at or before age 45 Invasive breast cancer diagnosed at/before age 50 with one or more of the following:
• •Limited family history (Fewer than 2 first- or second-degree female relatives in the same lineage that lived to age 45. The "limited family history" can occur on either the maternal or paternal side of the family.)
• •1 or more first-/second-degree relatives with invasive BC at/before 50
• •1 or more first-/second-degree relatives with invasive epithelial ovarian cancer (any age)
• •1 or more first- or second-degree relatives with male breast cancer
• •2 or more first- or second-degree relatives with pancreas cancer
• •Invasive breast cancer diagnosed at or before age 60 with at least 2 first or second-degree relatives affected with any combination of invasive breast cancer before age 50, invasive epithelial ovarian cancer at any age, male breast cancer, or pancreas cancer.
• •Full sequence BRCA1 and BRCA2 testing completed with no deleterious mutation identified.