Lead Sponsor

Wills Eye

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Age 18 and over
•Ability to give written informed consent
•Sub-retinal fluid under fovea seen on OCT
•Diagnosis of central serous chorioretinopathy (CSCR): classification is at the discretion of the investigator, but general guidelines are
•1. Acute- first episode or symptoms less than one month prior to presentation
•2. Chronic- previously documented sub-foveal fluid, any prior treatment, symptoms for over 3 months, or \<50% reduction in fluid thickness on OCT after 3 months.

•Age under 18
•Impaired decision-making ability
•At initial laboratory screening serum potassium \>5.5 milliequivalent (mEq)/L
•At initial laboratory screening serum creatinine \>2 mg/dL in men and \>1.8 mg/dL in women or decreased renal function by creatinine clearance less than 50 mL/min
•Absence of sub-foveal fluid
•Any patient with prior treatment for CSCR within 3 months of enrollment
•Patients taking potassium supplements or potassium-sparing diuretics spironolactone, amiloride, and triamterene and/or potent CYP3A4 (cytochrome) inhibitors (amifostine, cyclosporine, fluconazole, itraconazole, ketoconazole, mifepristone, posaconazole, potassium salts, rituximab, tacrolimus, voriconazole nefazodone, troleandomycin, clarithromycin, ritonavir, and nelfinavir)
•Women who are pregnant or are actively trying to conceive
•Patients with type 1 or type 2 diabetes