E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy

Exclusion Criteria

• •1. Mini-mental status exam score of less than or equal to 24;
• •2. Presence of a psychiatric disorder within previous year or a life time history of ADHD or psychotic disorder including bipolar disorder, schizoaffective disorder and schizophrenia;
• •3. Lifetime history of drug addiction or abuse, excepting nicotine;
• •4. Regular use of other psychotropic medication;
• •5. Regular use (more than once a week) of alcohol that is greater than 3 drinks per day;
• •6. Presence of a contraindication to treatment with stimulant medication; this would include the presence of hypertension (controlled or uncontrolled), coronary disease, atrial fibrillation, and arrhythmia;
• •7. History of seizures;
• •8. Presence of a contraindication to treatment with estrogen; this would include the presence of a history of blood clots, and estrogen-receptor positive breast cancer;
• •9. Claustrophobia;
• •10. History of cardiac disease including known cardiac defect or conduction abnormality;
• •11. Abnormal electrocardiogram during screening;
• •12. Current pregnancy or planning to become pregnant;
• •13. Presence of a metallic implant