Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hoffmann-La Roche
Age
18–55
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Body mass index (BMI) between 18 to 32 kilogram per square meter (kg/m\^2)
Male volunteers must use effective contraception as outlined in the protocol
Willingness to abstain from alcohol and xanthine-containing beverages or food (coffee, tea, cola, chocolate and "energy drinks") from 72 hours prior to the first dose until discharged
Willingness to avoid prolonged sun exposure and guard against sunburn during study and follow-up
You may not be if
Clinically significant medical history or findings in physical examination, vital signs, or laboratory test results prior to study start
Positive screening tests for hepatitis B or C, human immunodeficiency virus (HIV), alcohol, drugs of abuse, or tobacco
Women of childbearing potential, or males with pregnant or lactating partners
Regular smoking within 6 months prior to first dosing. Participants should avoid smoky environments for at least 1 week prior to each cotinine screen
Excessive alcohol consumption
Use of any metabolic inducers (including herbals such as St. John's Wort) within 4 weeks or 5 half-lives (whichever is longer) before the first dose of study medication, including but not limited to: rifampin, rifabutin, glucocorticoids, carbamazepine, phenytoin and phenobarbital
Strenuous activity, sunbathing, or contact sports are not allowed from 4 days prior to entry into the clinical site until study follow-up
Participation in an investigational drug or device study within 45 days (or 6 months for biologic therapies) prior to first dosing
