Effects of Niacin On Fatty Acid Trapping

Exclusion Criteria

• •Dysbetalipoproteinemia
• •History of extreme triglyceridemia (TG \>500 mg/dL) or pancreatitis from triglyceridemia, regardless of whether it is currently controlled
• •LDL \>190 mg/dL
• •History of chronic renal insufficiency (serum creatinine \>2.0 mg/dL)
• •History of non-skin malignancy within the previous 5 years
• •Subject reported history of HIV
• •Uncontrolled thyroid disease
• •Hypoalbuminemia (serum albumin \>2.5 mg/dL)
• •Exposure to an investigational drug within 6 weeks prior to the screening visit
• •Any major active rheumatologic, pulmonary, or dermatologic disease or inflammatory condition
• •Major surgery within the previous 6 weeks
• •Subjects who have undergone any organ transplant
• •History of drug abuse within the past 3 years, or regular alcohol use \>14 drinks per week
• •Women who are breast-feeding
• •Women who are pregnant by urine pregnancy test at each visit
• •Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study
• •Change in statin dose within 6 weeks of the first experimental visit
• •Use of the following non-statin lipid-altering therapy within 6 weeks of the first experimental visit: Niacin \> 100 mg/day (Niacor, Slo-Niacin, Niaspan, Advicor, or supplemental niacin), Fibrates \[gemfibrozil (Lopid), fenofibrate (Antara, Lofibra, Tricor, Triglide)\], Enterically active drugs \[colestipol (Colestid), cholestyramine (Questran), colesevelam (Welchol), ezetimibe (Zetia, Vytorin)\], Red yeast rice, Fish oil (Omacor, numerous supplements)
• •Use of medications indicated for the treatment of diabetes within 6 weeks of the screening visit
• •Known intolerance or contraindication to niacin (e.g., moderate to severe gout, severe peptic ulcer disease)
• •Medical condition that would prohibit fasting (e.g., diagnosis of insulinoma or postabsorptive hypoglycemia)
• •Significant disinclination to dairy products (e.g., lactose intolerance, inviolable dietary restrictions)
• •History of anaphylactic reaction
• •For indocyanine green substudy: iodine allergy or shellfish allergy (n.b. a subject with an allergy can participate in the overall experiment, but will forego the indocyanine green tracer study)
• •Donation of blood 8 weeks and/or treatment with medications for psychiatric disorders
• •Hemoglobin \<10 g/dL