Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations

Inclusion Criteria

• •1. Cystic fibrosis
• •2. Age \> 18 years
• •3. Stable maintenance medical regimen during the previous 6 weeks.
• •4. Negative pregnancy test (women of childbearing potential) at both screening and baseline visits.
• •5. Women of childbearing potential must be using medically acceptable contraception.
• •6. At least two respiratory exacerbations per year requiring oral and/or intravenous antibiotics for each of the two years prior to study entry, but no more than 4 exacerbations requiring intravenous antibiotics during either of those years.