Adult with primary diagnosis of Major Depressive Disorder
Aged from 18 years to 65 years
A primary diagnosis of Major Depressive Disorder based on the criteria in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM- IV-TR), single or recurrent episode, without psychotic features
Hamilton Psychiatric Rating Scale for Depression (HAM-D 17) total score of ≧ 20
Clinical Global Impressions Scale-Severity (CGI-S) score of ≧4
You may not be if
Known hypersensitivity to desvenlafaxine or venlafaxine
Significant risk of suicide based on clinical judgment
Women who were pregnant,breast-feeding,or planning to become pregnant during study
Had a history of seizure disorder
History or current evidence of gastrointestinal disease known to interfere with the absorption or excretion of drugs or a history of surgery known to interfere with the absorption or excretion of drugs
Any unstable hepatic, renal, pulmonary, cardiovascular, ophthalmologic, neurologic, or other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results
