Brain Mechanisms of Human Motivation

Exclusion Criteria

• •Suicidal ideation where outpatient treatment is determined unsafe by the study clinician
• •Pregnant women or women of childbearing potential who 1) have not completed a negative urine pregnancy test prior to the MRI scan and/or 2) are seeking to become pregnant or believe that they may be pregnant
• •Serious/unstable medical illness (e.g., cardiovascular, renal, endocrine, neurologic disease)
• •Clinical or laboratory evidence of hypothyroidism
• •History of seizure disorder, history or current diagnosis of dementia, score \< 26 on the MMSE at screening
• •History or current diagnosis of the following DSM-IV psychiatric illness: organic mental disorder, schizophrenia, schizoaffective disorder, delusional disorder, psychotic disorder NOS, patients with mood congruent or mood incongruent psychotic features, anorexia nervosa, obsessive compulsive disorder
• •Lifetime history of stimulant dependence (e.g., cocaine, amphetamines)
• •Current use of Methylphenidate (Ritalin) and other ADHD medications with dopaminergic effects
• •Patients with a lifetime history of electroconvulsive therapy (ECT)
• •Failure to meet standard MRI safety requirements